Application of Gap Mode Ultrasensitive P-GERTs in SERS-Based Rapid Detection

Application of Gap Mode Ultrasensitive P-GERTs in SERS-Based Rapid Detection

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In surface-enhanced Raman scattering (SERS) detection research, the shape, structure, surface modification, and material selection of nanoparticles can significantly impact the SERS intensity.Petal-like gap-enhanced Raman tags (P-GERTs) possess numerous sharp tips and edges, which generate localized electric field enhancements, further amplifying the electric field enhancement effect on neighboring molecules and enhancing the SERS signal.Additionally, the surface of P-GERTs can be modified with Quilt As You Go Technique functional molecules, enabling their application in the detection of disease biomarkers.Using COVID-19 as an example, the performance of P-GERTs in disease biomarker detection was validated, demonstrating that the signal intensity of this probe can reach 55 times that of regular gold nanoparticles and 36.

7 times that of smooth shell gap-enhanced Raman tags (S-GERTs).Furthermore, in combination with magnetically retrievable magnetic bead substrates, the N-protein antigen was specifically detected in a one-step process.N-protein was detected within 15 Input Filter min using a portable Raman spectrometer.The limit of detection (LOD) for the standard sample was 4.

28 pg/mL, and the LOD for the actual throat swab sample system was 25.4 pg/mL.This workflow can be extended to the detection of other biomarkers, making it widely applicable.